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Abstract

[/vc_column_text][vc_column_text]The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei reveals a similarity to E. coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of Gln339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia Lethal Factor 1 (BLF1).[/vc_column_text][vc_column_text]

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The BALB/c J774.2 macrophage cell line was cultured in DMEM supplemented with 10% fetal bovine serum (FBS; Biowest).

Learn more about Biowest’s standard fetal bovine serum and speciality fetal bovine serum.

DOI:

doi.10.1126/science.1211915[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1598017023330{margin-bottom: 0px !important;}”]

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