Atlantis Bioscience offers a wide range of live knockout (KO) and conditional knockout (cKO) mice supplied by GemPharmatech, a global leader in CRISPR-based mouse model generation. These models are developed as part of GemPharmatech’s Knockout All Project (KOAP)—an ambitious initiative to systematically generate KO and cKO mouse strains for all ~23,000 protein-coding genes in the mouse genome.

Building the World’s Largest Resource Library of Knockout (KO) and Conditional Knockout (cKO) Mice

Utilizing a high-throughput CRISPR-Cas9 platform, KOAP enables the efficient production of over 6,000 new mutant strains each year. To date, nearly 10,000 genes have been successfully targeted, including widely studied models such as Fmr1 knockout mice, Fto knockout mice, IL-10 knockout mice, Ifnar1 knockout mice, Ldlr knockout mice, LepR knockout mice, Rag1 and Rag2 knockout mice, Tlr4 knockout mice, TNF-α knockout mice, Trpv1 knockout mice, Wnt knockout mice, and AHR knockout mice. These models are valuable tools in research areas such as immunology, metabolism, oncology, neurology, and inflammation.

More than 200 Cre mouse strains are also available, enabling flexible and tissue-specific gene editing for conditional studies. These strains complement the cKO library, allowing researchers to create precise genetic models for diverse applications.

Select strains are available as live mice, reducing the time required for breeding and resuscitation. These mice can be shipped in as little as two weeks. Availability is regularly updated and fulfilled on a first-come, first-served basis.

Key Benefits:

• Live KO and cKO mice in stock and ready for shipment in as little as two weeks
• Developed under KOAP: the world’s largest initiative for generating KO and cKO mouse strains
• Over 22,000+ CRISPR-generated strains available, with continuous additions
• Popular strains include Fmr1, IL-10, Ifnar1, Tlr4, TNF-α, and Wnt knockout mice
• Custom model generation within 3–6 months if the desired strain is not available
• Free email alerts for selected live mouse strains
• Access to a full service platform including phenotyping, drug efficacy testing, and in vitro pathological analysis
• Convenient ordering via Atlantis Bioscience with expert support

Pathways and Diagrams

KO & cKO Mice

Cre Mice

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