Live Knockout Mice & Conditional Knockout Mice

Live Knockout Mice & Conditional Knockout Mice

Live Knockout Mice & Conditional Knockout Mice

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GemPharmatech’s ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome.

 

Our KO and cKO models can be used in a variety of research fields including oncology, autoimmunity, metabolism, and neurodegeneration.

 

Using CRISPR-Cas9 technology, we have also created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination.

 

These Cre mouse strains supplement our extensive cKO mouse library, allowing nearly unlimited genetic combinations to fit your research objectives.

 

We offer live mice for featured strains to save the time for breeding and resuscitation which may greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date, first come, first serve.

Benefits:

  • Live mice in stock and ready to ship in as soon as two weeks
  • Largest collection of CRISPR mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.
  • Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.

 

KO & cKO Mice

 

Strain ID

Targeted Gene

Strain Type

Background

Genotype

Application

T012747 Sting1 Cas9-KO C57BL/6JGpt Homozygous Viral Infections, innate Immunity, autoimmunity, Cellular Stress and autophagy
T010873 Nlrp3 Cas9-KO C57BL/6JGpt Homozygous Innate immunity, inflammatory response
T005534 Ifnar1 Cas9-KO C57BL/6JGpt Homozygous Viral infection, inflammatory response, oncology-immunity
T006659 Mettl3 Cas9-cKO C57BL/6JGpt Heterozygous M6A modification, cancers, etc.
T029037 Zbp1 Cas9-KO C57BL/6JGpt Heterozygous Inflammatory response, necroptosis
T002625 Nfe2l2 Cas9-KO C57BL/6JGpt Heterozygous Oxidative stress, inflammatory reaction, reproduction, etc.
T005545 Tnf Cas9-KO C57BL/6JGpt Heterozygous Developmental Biology,immune system,integument,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,Muscle ,respiratory system,adipose tissue,Cell Proliferation,Cell death,DNA transcription,reproductive system,digestive/alimentary system,Protein metabolism,liver/biliary system,renal/urinary system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,cellular,craniofacial ,growth/size/body,hematopoietic system,limbs/digits/tail,mortality/aging,Cell localization,Lipid Metabolism,Cytoplasmic vesicle,endosome,Organelles membrane,DNA binding protein,Physiological system,Metabolic research,Cell biology,Molecular biology
T007997 Nf1 Cas9-CKO C57BL/6JGpt Homozygous Metabolic research,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell
T011566 Shank3 Cas9-KO C57BL/6JGpt Homozygous Synapses, autism
T017245 Acss2 Cas9-KO C57BL/6JGpt Heterozygous Glucose metabolism,liver/biliary system,homeostasis/metabolism,Lipid Metabolism,cell nucleus,ligase,Metabolic research,digestive/alimentary system,Cell biology,Molecular biology,Physiological system
T018441 Acly Cas9-CKO C57BL/6JGpt Heterozygous Glucose metabolism,Mitochondrial research,mortality/aging,Lipid Metabolism,cell nucleus,Organelles membrane,transferase,Metabolic research,Cell biology,Developmental Biology,Molecular biology
T052147 Yap1 Cas9-CKO C57BL/6JGpt Heterozygous Hippo signaling pathway, development, growth, repair and endogenous homeostasis, cancer, etc.
T007891 Mfn2 Cas9-CKO C57BL/6JGpt Heterozygous Metabolic research,homeostasis/metabolism,Developmental Biology,embryo,growth/size/body,mortality/aging,nervous
T011513 Padi4-KO Cas9-KO C57BL/6JGpt Heterozygous Immune system,Protein metabolism,cellular,growth/size/body,hematopoietic system,mortality/aging,cell nucleus,hydrolytic
T016449 Acss2 Cas9-CKO C57BL/6JGpt Heterozygous Metabolic research,Glucose metabolism,homeostasis/metabolism,Lipid Metabolism,Physiological system,digestive/alimentary system,liver/biliary system,Cell biology,cell nucleus,Molecular biology,ligase
T019786 Sik2 Cas9-CKO C57BL/6JGpt Heterozygous Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,immune system,nervous system,behavior/neurological,Physiological system,integument,pigmentation,cardiovascular system,Muscle ,Cell biology,cellular,cell nucleus,Molecular biology,Signal Transduction,transferase
T051714 Tlr4 Cas9-KO C57BL/6JGpt Heterozygous Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,Physiological system,integument,pigmentation,cardiovascular system,skeleton,Muscle ,respiratory system,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Cytoplasmic vesicle,endosome,Golgi apparatus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,hydrolytic enzyme,Lipid binding protein
T008889 Fabp4 Cas9-CKO C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,Physiological system,renal/urinary system
T013731 Abcb11 Cas9-KO C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,Physiological system,renal/urinary system
T052437 Il33 Cas9-KO C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,Physiological system,renal/urinary system
T003346 Trem2 Cas9-KO C57BL/6JGpt Heterozygous Metabolic research,Protein metabolism,Glucose metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,immune system,nervous system,Physiological system,cardiovascular system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Organelles membrane,Molecular biology,Signal Transduction,Lipid binding protein,Disease and Drug Evaluation Model,Neurodegenerative diseases,Huntington’s disease
T016185 Mthfd2 Cas9-CKO C57BL/6JGpt Heterozygous Developmental Biology,embryo,growth/size/body,mortality/aging,nervous system,vision/eye,Physiological system,integument,cardiovascular system,skeleton,craniofacial ,digestive/alimentary system,liver/biliary system,Cell biology,Mitochondrial research,Molecular biology,hydrolytic enzyme,oxidordeuctase
T052860 Fap Cas9-KO C57BL/6JGpt Heterozygous Metabolic research,Protein metabolism,Developmental Biology,immune system,nervous system,vision/eye,Physiological system,skeleton,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Organelles membrane,Molecular biology,hydrolytic enzyme

 

 

Cre Mice

 

Strain ID

Targeted Gene

Strain Type

Background

Genotype

Application

T004711 Adipoq-P2A-iCre Cas9-KI C57BL/6JGpt Homozygous Theoretically labeled cell type: White adipose tissue, brown adipose tissue
T004714 H11-Vil1-iCre-ployA Cas9-KI(H11) C57BL/6JGpt Homozygous Theoretically labeled cell type: Gut epithelial cells
T050182 Rosa26-SA-CreERT2 Cas9-KI(Rosa26) C57BL/6JGpt Homozygous Expression system/tissue: Whole body (low activity in brain and skeletal muscle)
T004818 Cd4-iCre Cas9-KI(H11) C57BL/6JGpt Homozygous Theoretically labeled cell type: Helper T cells (CD4+ T cells)
T010829 Tg(Prox1-CreERT2) TG C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,immune system
T036859 Ckmm-iCre-PolyA TG C57BL/6JGpt Heterozygous Cre/Dre,Tool Mice,adipose tissue,Metabolic research
T052789 Lyz2-CreERT2 Cas9-KI C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,immune system
T009409 H11-Stra8-iCre Cas9-KI(H11) C57BL/6JGpt Homozygous Theoretically labeled cell type: Seminiferous epithelium, testicular mesenchymal cells, spermatocytes, oogenic cells
T004985 Lyve1-IRES-iCre Cas9-KI C57BL/6JGpt Heterozygous Expressed system/tissue: immune system; Theoretically labeled cell type: lymphatic vessel endothelial cells; no cellular level validation performed.
T004712 H11-Cdh5-iCre Cas9-KI C57BL/6JGpt Homozygous Theoretically labeled cell type: vascular endothelial cells
T006202 Calb1-P2A-iCre Cas9-KI C57BL/6JGpt Heterozygous Expressed system/tissue: nervous system (see strain information for details). Theoretically labeled cell type: central neuron; no cellular level validation performed.
T006768 Cx3cr1-iCre Cas9-KI C57BL/6JGpt Homozygous Expressed system/tissue: immune system (see strain information for details). Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; no cellular level validation performed.
T050183 Rosa26-EIIA-iCre Cas9-KI(Rosa26) C57BL/6JGpt Heterozygous Expressed system/tissue: systemic (see strain information for details). Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); no cellular level validation performed.
T004829 H11-Vil1-CreERT2-ployA Cas9-KI(H11) C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,Physiological system,digestive/alimentary system
T017784 alb-creERT2 Cas9-KI(H11) C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,Physiological system,digestive/alimentary system,liver/biliary system
T005635 H11-MMTV-iCre Cas9-KI(H11) C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre
T006205 Lrat-P2A-iCre Cas9-KI C57BL/6JGpt Homozygous Theoretically labeled cell type: Hepatic stellate cells
T052797 Fos-CreERT2 Cas9-KI C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,nervous system
T007046 Cdh16-CreERT2 Cas9-KI C57BL/6JGpt Homozygous Tool Mice,Cre/Dre,Physiological system,renal/urinary system
T014691 Cdh5-CreERT2 TG C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,Physiological system,cardiovascular system
T055135 Cd4-IRES-iCre Cas9-KI C57BL/6JGpt Heterozygous Tool Mice,Cre/Dre,immune system
T050812 Upk2-P2A-iCre Cas9-KI C57BL/6JGpt heterozygous Tool Mice,Cre/Dre,Physiological system,renal/urinary system
T052686 Cdh5-P2A-CreERT2 Cas9-KI C57BL/6JGpt heterozygous Tool Mice,Cre/Dre,Physiological system,renal/urinary system
T057690 Pi16-creERT2 Cas9-KI C57BL/6JGpt heterozygous Tool Mice,Cre/Dre,Physiological system,renal/urinary system
T052693 Aldh1l1-CreERT2 Cas9-KI C57BL/6JGpt Homozygous Tool Mice,Cre/Dre,nervous system