APC Anti-Human CD38 (HIT2)
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| Cat No. | Size | Price |
|---|---|---|
| 20-0389-T025 | 25 tests | $63.00 |
| 20-0389-T100 | 100 tests | $151.00 |
Description
The HIT2 antibody is specific for human CD38, a 45 kD type II transmembrane glycoprotein expressed on thymocytes, activated T and B cells, and monocytes as well as other non-hematopoietic cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.
The UCHT1 antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of UCHT1 antibody to CD3e can induce cell activation (use format suitable for functional assays). A recent publication of the crystal structure of a CD3e- antibody complex provides insight as to the action of commonly used agonist antibodies, as well as specific epitope-binding data for the human CD3 antibodies UCHT1 and OKT3 (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).
Product Details
| Name | APC Anti-Human CD38 (HIT2) |
|---|---|
| Cat. No. | 20-0389 |
| Alternative Names | Cyclic ADP-Ribose Hydrolase, ADP-Ribosyl Cyclase |
| Gene ID | 952 |
| Clone | HIT2 |
| Isotype | Mouse IgG1, kappa |
| Reactivity | Human |
| Cross Reactivity | |
| Format | APC |
| Application | Flow Cytometry |
| Citations* | Dianzani U, and Malavasi F. 1995. Crit. Rev. Immunol. 15(2):167-200.
Mehta K, Shahid U, and Malavasi F. Oct. 1996. FASEB J. 10(12):1408-1417. Ferrero E, and Malavas F. Feb. 1999. J. Jeukoc. Biol. 65(2):151-161. Matrai Z. Feb. 2005. Hematology. 10(1):39-46. |
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.
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