Discover what is NK cell therapy, how NK cells treatment works, and why this therapy kills cancer cells with minimal side effects. In this on-demand webinar, Dr Sergey Kulemzin—Head of Immunotherapy at Bodrost DOO and advisor to Atlantis Bioscience—shares cutting-edge insights on manufacturing clinical-grade NK cells for cancer and viral immunotherapy.

What Is NK Cell Therapy?

Natural killer (NK) cells are a frontline component of our immune system that can directly recognize and destroy tumor or virus-infected cells. Unlike T cells, NK cells do not require prior sensitization and exert rapid cytotoxic effects by tipping the balance toward activating signals over inhibitory cues.

Why Choose NK Cells Treatment?

Minimal Serious Side Effects
Clinical trials report very low incidence of severe adverse events—mostly mild fatigue or anemia.

Allogeneic Advantage
Donor-derived (allogeneic) NK cells evade self-MHC inhibition, delivering stronger anti-tumor responses compared to patient-derived (autologous) cells.

Synergy with Checkpoint Inhibitors
Combining NK cell therapy with pembrolizumab or radiation can overcome tumor resistance mechanisms.

Key Topics Covered

1. Understanding NK Cell Activation

• Activation depends on a delicate balance between activating and inhibitory receptors.
• Strong activating signals trigger release of perforin and granzymes, eradicating cancer cells.

2. Diverse Sources of NK Cells

• Peripheral Blood: Readily available but variable yield.
• Cord Blood & iPSCs: Offer scalable, uniform “off-the-shelf” products.
• NK-92 Cell Lines: Cost-effective, though require irradiation before patient infusion.

3. Clinical-Grade NK Cell Expansion

• Feeder-Free Protocols: Antibody-coated surfaces + optimized cytokine cocktails reduce contamination risk.
• Quality Control: Aim for ≥ 98% NK purity with minimal T-cell carryover.

4. Safety Considerations in NK Cell Therapy

• Infection Screening & MHC Genotyping: Essential regulatory checkpoints.
• Vector-Related Patents: Novel baboon-virus envelopes improve CAR-NK transduction efficiency.

5. Mechanisms of Action & Overcoming Tumor Barriers

• Poor Biodistribution and inhibitory ligands on tumors can limit efficacy.
• Combination Strategies: Radiation, checkpoint inhibitors, or CAR engineering can boost tumor penetration and killing.

Ready to learn more? Watch the full webinar to dive deeper into protocols, clinical data, and emerging trends in NK cell therapy.

Off-the-Shelf NK Cell Expansion Kit (Recommended by Dr Sergey)

To streamline your clinical-grade NK cell manufacturing, Atlantis Bioscience now offers the Selective KBM Human NK Cell Culture Kit (KOHJIN Bio). This feeder-free, ready-to-use solution gives you:

• Pre-optimized activation cocktail tuned for maximal NK proliferation
• GMP-grade cytokines supplied directly by Atlantis Bioscience
• Feeder-free protocol—no extra cleanup or feeder-cell removal assays needed

Skip time-consuming optimization and get straight to high-yield, GMP-compliant NK expansion. Contact us today to learn more and place your order.