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The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, in vivo, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV. Moreover, such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses, likely due to a unique feature of IAV to elevate ACE2 expression. This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection, and thus, prevention of IAV infection is of great significance during the COVID-19 pandemic.[/vc_column_text][vc_column_text]
In this study, K18-hACE2 transgenic mice from GemPharmatech (strain ID, T037657) was used to study tudy the interaction between influenza A virus (IAV) and SARS-CoV-2 in vivo.
Explore our hACE2 transgenic or KO mouse models.
10.1007/s13770-021-00352-1.[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text]
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Wu Q, Liang X, Wang K, et al. Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis. Cell Metab. 2021;33(10):1988-2003.e7. doi:10.1016/j.cmet.2021.07.007
Li, Y., Lu, Y., Lin, SH. et al. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol 22, 1175–1185 (2021). https://doi.org/10.1038/s41590-021-01010-3
Shao, F., Liu, Q., Zhu, Y. et al. Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis. Nat Commun 12, 6540 (2021). https://doi.org/10.1038/s41467-021-26750-6
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