Y-27632 dihydrochloride: Potent and Selective ROCK Inhibitor for Your Research

TargetMol is proud to offer Y-27632 dihydrochloride (Y-27632 2HCl), a highly selective and cell-permeable inhibitor of Rho-associated protein kinase (ROCK). Up to 99.98% purity.

Key Features:

• Potent and Selective: Specifically inhibits ROCK-I and ROCK-II with high potency (IC50 values in the low micromolar range)
• Cell-Permeable: Easily enters cells for effective intracellular targeting
  Wide Range of Applications: Used in studies of stem cell biology, neuronal differentiation, fibrosis, and more (see references below)
• Available in Multiple Sizes: To suit your research needs

Applications:

• Stem Cell Research: Promotes survival and expansion of various stem cell types, including iPSCs and ADSCs [1, 2].
• Neuronal Differentiation: Induces neuronal differentiation in stem cells [2].
• Fibrosis Research: Reduces liver fibrosis and collagen deposition [5].
• Motor Neuron Disease Studies: Shows promise in improving motor function in ALS models [4].
• And many other ROCK-related research areas!

In Vitro References:

• [1] Improvement of Cloning Efficiency of Marmoset iPSCs by Rho Kinase Inhibitor Y-27632
• [2] Induction of Neuronal Differentiation in Adult Adipose Tissue-Derived Stem Cells by Rho Kinase Inhibitor Y-27632
• [3] Effect of Rho Kinase Inhibitor Y-27632 on the Proliferation and Survival of Crab Monkey Embryonic Stem Cells

In Vivo References:

• [4] The Therapeutic Potential of Rho-Kinase Inhibitors in a Mouse Model of Amyotrophic Lateral Sclerosis
• [5] Y-27632, a Rho-Kinase Inhibitor, Ameliorates Hepatic Fibrosis Induced by Dimethylnitrosamine in Rats

Please note: This product is for research purposes only. Request for Quote for pricing.