RNase-X™ Decontamination Solution

RNase-X™ Decontamination Solution

RNase-X™ Decontamination Solution eliminates RNases from benchtops, pipettors, tip boxes, and instruments—ensuring RNA integrity in every experiment.

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Reliable Protection Against RNase Contamination for RNA Research

Working with RNA is notoriously challenging due to the ubiquitous presence and stability of RNases. These enzymes are resistant to heat and many chemical treatments, making routine laboratory decontamination ineffective.

RNase-X™ Decontamination Solution is specifically designed to safeguard RNA integrity by eliminating RNase contamination from laboratory work surfaces and equipment. From benchtops and pipettors to tip boxes and instruments, RNase-X™ offers a simple, effective, and affordable solution for maintaining RNase-free conditions.

Conveniently supplied in a ready-to-use spray bottle, RNase-X™ makes decontamination easy: simply spray, wipe, and rinse with RNase-free water or 70% ethanol.

Key Features

  • Effective RNase removal: Proven to eliminate RNase contamination on laboratory surfaces.
  • Wide application: Ideal for benchtops, pipettors, tip boxes, and sensitive instruments.
  • Ready-to-use format: Supplied in a convenient spray bottle for immediate application.
  • Cost-effective: Delivers excellent performance at a lower cost than RNaseZap™.
  • Protects RNA integrity: Ensures reliable results in sensitive RNA research workflows.
Figure showing effectiveness of RNase-X™ Decontamination Solution. (A) Gel electrophoresis: intact RNA bands in water and RNase + RNase-X™ samples, but degraded RNA in RNase + water control. (B) Bar graph: RNase activity is nearly 100% in RNase + water, but reduced to background levels with RNase-X™, confirming RNase removal from surfaces.
RNase-X™ effectively removes RNase from surfaces. To simulate RNase-contaminated surfaces, the insides of microfuge tubes were left untreated (water), or coated with RNase A, then rinsed with either water or RNase-X™, followed by water washes. A. The final water washes were incubated with total human RNA, which was then stained with EMBER500™ RNA Prestain Loading Dye and analyzed on an agarose gel. First two lanes: RNA incubated with water alone. Middle two lanes: RNA incubated with the water from RNase-treated, water-rinsed tube. Last two lanes: RNA incubated with the water from RNase-treated, RNase-X™-rinsed tube. B. Analysis of RNase activity in the final water
washes using the RNaseAlert™ assay from IDT.

Applications

  • RNA extraction and purification workflows
  • cDNA synthesis and RT-qPCR
  • RNA sequencing (RNA-seq)
  • mRNA and saRNA vaccine research
  • Gene expression analysis

How to Use

  1. Spray RNase-X™ directly onto the work surface or instrument.
  2. Wipe clean with a lint-free tissue or cloth.
  3. Rinse with RNase-free water or 70% ethanol.

For research use only. Not for use in diagnostic procedures.

*Biotium Products are only available in Singapore and Thailand.