Immunodeficient Mouse Models

Immunodeficient Mouse Models

Immunodeficient Mouse Models

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NCG is a triple-immunodeficient mouse model. It is the first CRISPR-generated immunodeficient model developed by altering the Prkdc and Il2rg genes. It is the most immunodeficient model to date and is suitable for cells/tissues xenograft and human immune system components transplantation, enabling researchers to further study tumour biology and immuno-oncology.

The NCG model is well validated and has been available in the North American market since 2016. It is now accessible to the users in the Asia/Pacific market.

NOD/ShiLtJGPT —–> Macrophage and DC deficient
Prkdc knockout —–> Absence of T cells and B cells
Il2rg knockout —–> Absence of NK cells

Strains Function
NCG-SGM3 Promote the development of myeloid lineages and lymphoid cells
NCG-hIL15 Promote the development of NK cells
NCG-X Able to engraft functional T cells without irradiation, and promote erythroid development in BM
NCG-hIL6 Enriched CD14+ monocyte and macrophage differentiation
NCG-hIL7 Promote the development of T and B cells
NCG-hBAFF Promote the development of B cells
NCG-hIL2 Promote the development of T cells and NK cells
NCG-B2M-KO Relatively resistant to graft versus host disease (GvDH)
  • Our comprehensive portfolio of NCG and next-generation NCG mice enables excellent engraftment of human PBMCs, HSCs, and human tumor tissues.
  • Our proprietary NCG strains have an extended life span of greater than 90 weeks—approximately 15 weeks longer than for other severe immunodeficient mouse models.
  • One of our next-generation NCG strains, NCG-X, enables engraftment in the absence of irradiation, promising better animal health and reduced experimental complication.
  • Our large selection of PDXs provides preclinical tools for drug screening, biomarker development, and personalized medicine.
  • Our collection of CDXs provide a renewable source of patient tumor materials that can be used for a variety of research applications.


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Immunodeficient mouse model