Human Immune System Reconstituted NCG
Human Immune System Reconstituted NCG
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There is a growing demand for specialised mouse models with human immune systems for drug development in cancer, infectious and autoimmune diseases. Immunodeficient mice are often used for this purpose, as they have shown to engraft human cells and tissues more efficiently than other models.
Our models utilise the NCG immunodeficient mouse model that lacks the mouse’s natural immune system to create an environment with human immune cells.
Comparison of huPBMC-NCG and huHSC-NCG mice
| huPBMC-NCG mice | huHSC (CD34+)-NCG mice | |
| Irradiation | No | Yes |
| GvHD | High | Low |
| Reconstruction period | 2 weeks | 8-10 weeks |
| Human immune cells | T cells | T cells, B cells, NK cells,
Myeloid cells |
| Available time | 4-5 weeks | > 18 weeks |
| Summary | Ideal model for short-term study | Ideal model for long-term study |
Documents
Human immune system reconstitute NCG
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