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Dupilumab

Categories, Drug Discovery & Development, Immunooncology, Inhibitors and Compound Libraries, Inhibitory Antibodies

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Dupilumab

Dupilumab

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Categories: Categories Drug Discovery & Development Immunooncology Inhibitors and Compound Libraries Inhibitory Antibodies Tags: 1190264-60-8 Dupilumab IL Receptor Immunology/Inflammation inhibit Inhibitor REGN-668 SAR-231893 Brand: TargetMol

Description

Dupilumab (RegN-668) can inhibit IL-4 and IL-13 signaling pathways and significantly improve moderate to severe atopic dermatitis.It is a human monoclonal antibody (IL-4r-inhibitor) that completely inhibits il-4 receptors.

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Description

Dupilumab (RegN-668) can inhibit IL-4 and IL-13 signaling pathways and significantly improve moderate to severe atopic dermatitis.It is a human monoclonal antibody (IL-4r-inhibitor) that completely inhibits il-4 receptors.

In vitro

Dupilumab suppressed mRNA expressions of genes related to activation of T cells, DCs, eosinophils, inflammatory pathways, and TH2-inducing chemokines in skin lesions. No significant reduction in IL-17A or IL-22 levels is detected, but large reductions in expression of IL-17–related genes, such as elafin (PI3), IL23p19/IL23A, and S100A8 and trends for suppression (CXCL1 and S100A7) are found with 300 mg of Dupilumab. Major suppressions of hyperplasia-related genes (eg, K16) and reductions in expression of S100A genes are evident with 300 mg of Dupilumab by using microarrays and qRT-PCR.

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Synonyms	SAR-231893, REGN-668
Molecular Weight	N/A
CAS No.	1190264-60-8

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1. Hamilton JD, et al. Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 2014 Dec;134(6):1293-1300.

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