ACE2 Mouse Models – Humanized and Conditional/Knockout Mice

Mouse models play a critical role in both vaccine and drug development. Studies have shown that SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2) receptor on the surface of human cells through the spike protein (S protein).
Many different hACE2 transgenic mouse models have been developed for in vivo experimental platform for COVID-19 research. We are prioritizing our support in COVID-19 research. Check out the list of ACE2 mouse models in the table below.

ACE2 Mouse Models

Selected Publications:

Ma X, Zou F, Yu F, et al., Nanoparticle vaccines based on the receptor binding domain (RBD) and heptad repeat (HR) of SARS-CoV-2 elicit robust protective immune responses. Immunity 2020 53(6):1315-1330. e9; doi.org/10.1016/j.immuni.2020.11.015 (IF: 31.745)
Qiao J, Li Y-S, Zeng R, et al., SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science 2021;371(6536):1374-1378; DOI: 10.1126/science.abf1611 (IF 47.728)
Li T, Han X, Gu C, et al., Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. Nature communications 2021;12(1):1-11; doi.org/10.1038/s41467-021-26539-7 (IF: 14.919)
Zhang S, Huang W, Ren L, et al., Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2. Cell Research 2021:1-15 doi.org/10.1038/s41422-021-00581-y (IF:25.617)

Custom Animal Models for COVID-19 Research

We also offer custom animal models to meet the requirements for your COVID-19 study. If you need other COVID-19 models, send in your inquiries and we will assist you.

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