Reliable Freeze-Drying of EVs Without Compromising Functionality

EVSafe Lyophilization Buffer is a 4X optimised formulation developed to protect extracellular vesicles (EVs) during freeze-drying, enabling long-term, room-temperature storage without compromising vesicle integrity or biological activity. This ready-to-use buffer delivers ~85% EV recovery post-lyophilisation, maintaining particle morphology and functional cargo delivery.

Validated across a variety of EV sources—including red blood cell-derived, mesenchymal stromal cell-derived, and plant-derived EVs—this formulation is free from interfering additives such as membrane-permeating agents, protein-based cryoprotectants, synthetic polymers, lipids, or organic solvents. Its components are fully removable by a single centrifugation or standard EV purification method.

Key Features & Benefits

• ✅ High Recovery Efficiency: ~85% EV recovery post-lyophilisation

• ✅ Maintains EV Morphology: Prevents clumping and supports intact vesicle structure

• ✅ Functional Cargo Integrity: Preserves bioactivity for downstream assays

• ✅ Room-Temperature Storage: Simplifies logistics and handling post-freeze-drying

• ✅ Ready-to-Use Format: 4X concentration for easy integration into purified EV samples

• ✅ Broad Compatibility: Validated for RBC-EVs, MSC-EVs, and plant EVs; compatible with EVFect and EVCraft kits from Jotbody

Why Choose EVSafe?

As EV research accelerates across translational hubs, maintaining the integrity of your extracellular vesicles from bench to bedside is critical. EVSafe™ Storage Buffer is your reliable partner for safeguarding EV quality during storage, ensuring reproducibility and efficiency in your workflow—whether for regenerative medicine, oncology, or biomarker discovery.

Part of the EVSafe Collection:

• Storage | Lysis | Lyophilisation – Integrated protection at every EV handling stage
• High reproducibility across experiments
• Reliable, additive-free formulation

Note: These products are distributed only in Singapore and Thailand.