CoverGrip™ Coverslip Sealant
A microscopy-safe sealant that protects wet-mounted coverslips to ensure clean, stable fluorescence signals for reliable imaging results.
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Precision Sealing for Reliable Fluorescence Imaging
Nail polish was never made for microscopy. Its solvents can leach into your mounting medium, distort fluorescence and damage delicate samples. After hours of staining and imaging prep, you deserve a sealant that won’t silently sabotage your work. CoverGrip™ protects your signal so your data stays true.
CoverGrip™ delivers a clear, durable seal for wet-mounted coverslips without fluorescence interference. Formulated with microscopy-safe ingredients, it prevents leaching, preserves signal integrity and replaces nail polish for high-quality imaging.
Key Features
- Engineered to protect fluorescence signals
- Clear, hard, durable seal that stays stable over time
- No leaching into aqueous mounting medium
- Kinder to delicate samples than nail polish
- Fast drying for smoother workflows
- Clean d-limonene formula with a gentle citrus scent
- Available in lab-friendly 15 mL and 100 mL formats
CoverGrip™ vs Nail Polish
| Feature | CoverGrip™ Coverslip Sealant | Nail Polish |
|---|---|---|
| Fluorescence Safety | No leaching or signal disruption | Can leach and distort fluorescence |
| Specimen Integrity | Gentle and microscopy-safe | Harsh solvents can damage samples |
| Seal Quality | Clear, durable, stable | Shrinking, cracking or leaching over time |
| Drying Time | Fast, smooth workflow | Often needs overnight drying |
| Purpose | Designed for microscopy | Not intended for scientific imaging |
Why Choose CoverGrip™
Choose CoverGrip™ when you need a sealant that protects your fluorescence signal, preserves sample integrity and ensures stable mounting for long-term microscopy. Ideal for researchers who demand clarity, consistency and reliability in every imaging session.
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*Biotium Products are only available in Singapore and Thailand.
Specification
| Attribute | Detail |
|---|---|
| Sizes | 15 mL (#23005) |
| 100 mL (#23005-1) | |
| Composition | d-Limonene-based microscopy-safe sealant |
| Finish | Clear, hard, durable |
| Storage | Room temperature |
| Application | Sealing wet-mounted coverslips for fluorescence microscopy |
Citations
Citations Featuring CoverGrip™ Coverslip Sealant
CoverGrip™ is trusted by leading researchers and cited across high-impact journals for securing coverslips during fluorescence imaging. Below is a curated list of peer-reviewed publications demonstrating its use in advanced microscopy workflows.
Andrews et al., Nature Biomedical Engineering (2025)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue.
Used CoverGrip™ Sealant (Biotium, 23005) to secure coverslips for fluorescence imaging of brain tissue sections.
Yung et al., Journal of Extracellular Vesicles (2024)
Neonatal enteroids absorb extracellular vesicles from human milk-fed infant digestive fluid.
Enteroids were mounted and sealed with CoverGrip™ Coverslip Sealant for confocal imaging.
Guan et al., Cell Metabolism (2024)
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.
Applied CoverGrip™ to secure slides, improving preservation and clarity of fluorescence samples.
Bhagchandani et al., Science Immunology (2024)
Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with germinal center responses.
Sections were mounted and sealed immediately using CoverGrip™ Coverslip Sealant for confocal imaging.
Siew et al., Nature Communications (2024)
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction.
Slides sealed with CoverGrip™ Sealant (Biotium, 23005) for high-resolution immunofluorescence microscopy.
