BMP-14, Human

BMP-14, Human

BMP-14, Human

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Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. BMP-14 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development. Recombinant human BMP-14 is a 27 kDa homodimeric protein consisting of two 120 amino acid polypeptide chains.

SPISILFIDSANNVVYKQYEDMVVESCGCR with polyhistidine tag at the C-terminus

Escherichia coli

Endotoxin Test:
<0.1 EU per 1 μg of the protein by the LAL method. Activity:
Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is <14 ng/mL. Purity:
>98% as determined by SDS-PAGE. Ni-NTA chromatography

The protein was lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5.

It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.

Please use within one month after protein reconstitution.