Product Description
Circulating Tumour Cells (CTC)
CTC is rare (1 in 109 cells) – detecting CTCs with high sensitivity and specificity is a major challenge. Our CTC enrichment kit is the most sensitive platform with high specificity – EpCAM antibody with the highest binding affinity (Kd < 10-12).
- It can be used with liquid Biopsy – detecting cancers through a simple blood draw
- Â Clinical data in breast, colorectal, gastric, head & neck, non-small cell lung cancers across 4 notable teaching hospitals in Taiwan.
- Â 2 paper citations by CellSearch Inventor (Professor Leon Terstappen)
- —  Detects CTCs in >95% of patients enrolled (n > 125)
- —  Capturing live CTCs for culturing (success rate reaching ~96%, n = 50)
- —  Successfully performed NGS on CTCs captured from patients
- —  Can capture CTC with low EpCAM Expressions (e.g., CTCs with EMT, MDA-MB-231)
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Company | Technology Platform | Sensitivity | Specificity | Culturing & Sequencing | Capturing Clusters | Pricing |
---|---|---|---|---|---|---|
BioMab | Anti-EpCAM Antibody (EpCAM Ab, Kd < 10^-12) conjugated with magnetic beads  Anti-EpCAM Antibody highest binding affinity in |
High | High | ✓ | ✓ | Low |
Competitor A | Microfluidics coated with antibodies | Low | Low | X | X | Low |
Competitor B | Anti-EpCAM antibody conjugated with magnetic beads | Low | High | X | X | High |
Competitor C | Microfluidics plus anti-EpCAM antibody conjugated with magnetic beads |
Low | High | X | X | High |
Competitor D | Microfluidics based on cell size | High | Low | ✓ | ✓ | High |
Competitor E | Antibody and FISH probes | Low | High | ✓ | X | Low |
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